Talk by David Fleet, University of Toronto

Title: Multi-View 3D Reconstruction at Atomic Resolutions

Abstract:

Electron Cryo-microscopy (Cryo-EM) is a vision-based technique for estimating the 3D structure of biological molecules (eg proteins or viruses) at atomic resolutions. It addresses one of the foremost research problems in biology, namely macromolecular structure discovery. The problem, in a nutshell, is a form of multi-view 3D structure determination, inferring the 3D electron density of a particle from a large set of 2D images from an electron microscope.

I'll outline the nature of the problem and several contributions that have led to a new generation of cryo-EM algorithms now having a major impact in this emerging field.